Effects of Glycemic Index on Neuroplasticity, Systemic Inflammation and Epigenetic Longevity in Man and Animals
Keywords:
epigenetics, nutrition, carbohydrates, obesity, diabetes, neuroinflammation, neuroapoptosis, senescence, T2DM, Obesity, Nutrition, therapeutics, aging, lifestyle, epidemiology, metabolism, Glycated hemoglobin, wound healingAbstract
The pathophysiologic sequelae of systemic inflammation is a common observation in obesity and T2DM and contributes to the stigmata of the comorbidities linked to the disorder. Multiple factors contribute to the systemic inflammation, including elements of lifestyle, dietary macronutrient, micronutrient, and caloric intake, genetic predisposition, and the magnitude of the excess body fat accretion. The interaction between epigenetic metabolic factors and the above contributors remains unclear but include the quantity, type and glycemic index of the carbohydrates consumed. Carbohydrates with a high glycemic index contribute to greater excursions in glycemic and insulinogenic parameters, increase the generation of reactive oxygen species (ROS) and contribute to neuronal dysregulation and epigenetic senescence in man and animals.
