Evaluation of Salivary C-Reactive Protein in Smokers with Periodontitis in Khartoum state

Abstract

Objectives: Smoking widely affects oral health, including its role in the development of periodontitis. C - reactive protein (CRP) is an inflammatory biomarker that can be easily determined in saliva. This study was designed to assess Salivary C-Reactive protein in smokers with periodontitis.

Material and Methods: The study was a prospective cross-sectional study, conducted in Khartoum during the period from January to April 2023. One hundred participants were enrolled in this study, 50of them were cases (cigarette smokers with periodontitis), and the remaining 50 nonsmokers with healthy periodontium as the control group, saliva samples were collected for the assessment of the C reactive protein levels.

Results: Smokers with periodontitis had significantly higher levels of CRP compared to the control group (7.99 ± 0.44 vs 2.38±0.07 mg/L, p=0.000). Additionally, there was no correlation between the level of CRP and the age of the patients (p=0.9, r=0.018). also, no correlation was found between the level of CRP and the duration of smoking (p=0.611, r=0.074).

Conclusion: There were significant increase in salivary C reactive protein levels among study group, no correlation between age and duration with C reactive protein level.