Paraneoplastic hyperthyroidism secondary to metastatic choriocarcinoma. Clinical Case Report.
Keywords:Hyperthyroidism, Choriocarcinoma, Metastasis
Rarely, thyrotoxicosis may arise as a paraneoplastic syndrome, as in the case of choriocarcinoma. Similarities in biological structures between serum human chorionic gonadotropin (HCG) and thyroid stimulating hormone (TSH) allow HCG to exert its effects on the TSH receptor on thyroid membranes. Thyrotoxicosis was presented in a 25-year-old female patient who previously presented deterioration of alertness, intracranial hypertension, with subsequent finding of multiple metastatic lesions, with concentrations of human chorionic gonadotropin up to 500,000 mIU/mL. With adequate evolution after initiation of antithyroid and chemotherapy.
To report a case of rare pathology and review the literature to know the right approach to a case of paraneoplastic