Biological Clocks, Low-Cost Biomarkers, and AI for Healthspan Equity

Timothy Beckman — Sat, 10 Jan 2026 00:00:00 +0530

Biological clocks are central regulators of metabolism, immunity, cognition, and psychological well-being. Longevity medicine increasingly leverages sophisticated aging clocks, biomarker panels, and artificial intelligence (AI) analytics to support clients’ longevity efforts. These services are largely inaccessible to all but the most affluent populations. This paper qualitatively synthesizes recent research on biological clocks, health inequities, low-cost routine laboratory tests, and AI-enabled decision support to explore how rhythm-aligned, biomarker-driven, holistic wellness guidance can be made accessible to economically marginalized populations lacking consistent access to high end longevity medicine.

This research focused on a qualitative meta-synthesis of empirical and conceptual studies published between 2020 and 2025 targeting biological clocks, circadian health disparities, low-cost biomarkers, and AI-supported digital health in underserved communities. Twenty-two peer-reviewed articles met the inclusion criteria and were analyzed using a coding framework. Emergent themes included:

(1) biological clocks provide a cross-cutting framework linking healthspan to daily behaviors, social determinants, and
systemic inequities;
(2) circadian disruption and poor sleep health disproportionately affect low-income communities;
(3) standardized, low cost lab tests offer practical proxies for biological aging and healthspan risk;
(4) hair cortisol concentration (HCC) and related biomarkers provide a scalable window into chronic stress load in
marginalized settings;
(5) AI-enabled tools can translate routine lab data and symptoms into tailored, culturally grounded guidance aligned
with biological clocks; and
(6) structural barriers must be actively addressed to ensure that AI-supported rhythm-informed care reaches marginalized
communities.

Biological clocks and routine laboratories together create a “layman’s toolkit” that can be delivered at scale. When integrated into community-based health programs using low-cost digital platforms, these tools have the potential to extend healthspan for communities excluded from concierge longevity resources. Future research should evaluate the efficacy of these low-cost tools in a longitudinal study within marginalized societies.

Will Community Dwelling Older Adults Who Sustain a Non injurious Fall Benefit from Prophylactic Vitamin C Supplementation? A Review of Vitamin C and Bone Specific Influences and Observations Past and Present

Ray Marks — Sat, 31 Jan 2026 00:00:00 +0530

Fractures and their causative and repair mechanisms have been topics subject to various forms of investigation for several decades and are of particular salience in limiting healthy aging. In both instances, preventing and treating bone fractures - an immense societal concern in all aging populations – is a highly understudied topic. In this paper we discuss a possible role for vitamin C or ascorbic acid in both these processes in the context of secondary fracture prevention post falls, a topic that has received increasing attention in recent years, but with quite limited mainstream practice applications. It explores whether vitamin C is of potential relevance in preventing osteoporosis, a bone thinning disease linked to a high risk of future fractures in recurrent older age fallers, as well as in fostering bone fracture healing. While further investigation of this topic is warranted, ensuring aging adults have sufficient access to fruits and vegetables containing vitamin C as a rule and especially after an injurious fall or fracture appear to have considerable merit. Indeed, findings as of January 20, 2026 show a growing albeit imperfect degree of support for vitamin C in fostering bones mineral density metabolism as well as bone repairs.

International journal of Complementary and Internal Medicine

Biological Clocks, Low-Cost Biomarkers, and AI for Healthspan Equity

Will Community Dwelling Older Adults Who Sustain a Non injurious Fall Benefit from Prophylactic Vitamin C Supplementation? A Review of Vitamin C and Bone Specific Influences and Observations Past and Present