https://ijcimjournal.com/index.php/1 <p><span style="font-weight: 400;">International journal of Complementary and Internal Medicine is a peer-reviewed Open Access journal medical journal considers articles on internal medicine. It deals with the prevention and treatment of adult diseases, Emergency and veterinary medicine. We accept Research articles, review articles, case reports, short communications, Editorials etc.</span></p> Impact Factor: 0.0286 en-US International journal of Complementary and Internal Medicine 2835-155X https://ijcimjournal.com/index.php/1/article/view/76 <p>The onset and progression of subjective cognitive decline (SCD) in aging typically occurs gradually over an extended duration, often escaping recognition by friends and family during the early stages of the disorder. The incidence of SCD in developed counties, where the abundant consumption of refined carbohydrate sources is also commonplace, is virtually staggering, currently approaching over 10% of the population over age 45 with no definitive end in sight.1 The development of SCD has been associated with factors of socioeconomic, educational, metabolic and pathophysiological comorbidities, including diet and impaired insulin sensitivity common to obesity, Type 2 and 3 diabetes (T2DM; T3DM). While early intervention is preferable for the treatment of many illnesses and disorders, effective remedies for the senescence of aging and SCD remain a challenge for the practicing clinician, in part because the metabolic and nutritional factors which initiate the process remain largely unclear. The development of symptoms consistent with subclinical hypothyroidism (SCHT) are also commonplace among the aged. The independent contributions of thyroidal dysregulation and insulin resistance to dysregulation of energy balance, although strongly linked, some aspects remain unclear and incompletely known. Several<br>recent studies have now associated obesity and insulin resistance (IR) to brain senescence in aging congenic obese rats. Several studies also support a link between chronic hyperinsulinemia, epigenetic expression of obesity, brain shrinkage and decreased brain protein and cellular deoxyribose nucleic acid (DNA) content in a congenic rodent model of early onset obesity.<br><br>Aging congenic obese LA/Ntul//-cp rats develop obesity and hyperinsulinemia soon after weaning regardless of diet and which pathophysiologic stigmata persist throughout their lifespan. The stigmata of insulin resistance may become further aggravated when fed a high glycemic index diet. Groups of lean and obese rats were fed USDA-formulated nutritionally complete isoenergetic diets continuing cornstarch (ST) or sucrose (SUC) asthe only carbohydrate source from weaning until 10.5 months of age. Longevity of obese &lt;&lt; lean in both sexes. Obese rats were found to exhibit SCHT and decreased brain mass associated with IR, and accompanied with proportionate decreases in brain lipid, protein and DNA content in the obese but not the lean phenotype. In addition, the decreases in brain mass, protein and DNA composition were of greater magnitude when fed the SUC vs the ST diets in both phenotypes. These observations are suggestive of an increased potential for a contribution of the metabolic sequelae of insulin resistance as a pathophysiologic factor in the progression of brain shrinkage and presumed cognitive decline in the aging obese, hyper insulinemic rat, analogous to clinical observations which may occur in senescence, dementia and Alzheimer’s disease in aging populations and implicate the glycemic index of the refined carbohydrate source as a contributory factor.</p> Orien L Tulp Copyright (c) 2025 2025-08-17 2025-08-17 6 4 408 417 https://ijcimjournal.com/index.php/1/article/view/81 <p>Objective: To investigate the clinical conditions and sociodemographic characteristics associated with mortality due to COVID-19 during the first year of the pandemic in an intensive care unit in a capital city in northeastern Brazil. <br><br>Method: This was an exploratory, retrospective documentary study based on secondary data obtained from medical records of patients admitted to an intensive care unit of a public hospital in northeastern Brazil. Data collection occurred between July and September 2021. The data were analyzed via descriptive and inferential statistics. The chi-square test, Fisher's exact test, Student's t test, and binary logistic regression modeling were employed. The study was approved by the Research Ethics Committee. <br><br>Results: A total of 274 patients, predominantly male, mixed-race, and aged over 65 years, were included. The variables male sex, age 65 years or older, marital status (married), and length of hospital stay were significantly associated with clinical outcomes. Logistic regression analysis revealed that male individuals, those aged 65 years or older, those requiring invasive mechanical ventilation, and patients in the prone position had higher odds of mortality as an outcome.</p> <p><br>Conclusions: Observing the factors associated with mortality outcomes in patients affected by novel coronavirus infection can aid healthcare professionals and public health managers in decision-making.&nbsp;</p> Cindhy Mífia da Silva Moreira Fabiana Maria Rodrigues Lopes de Oliveira João Victor Batista Cabral Maria Hellena Ferreira Brasil Deysianne Ferreira da Silva Keylla Talitha Fernandes Barbosa Copyright (c) 2025 2025-08-17 2025-08-17 6 4 418 426