International journal of Complementary and Internal Medicine

Should Low-Dose Biophotonic Therapy Have a Role in the Treatment of Type 2 Diabetes (T2DM)

2025-02-07T04:20:25+00:00

Humans have always instinctively sought daylight and the sun’s rays for many generations while seeking relief from many sorts of illnesses including infectious illnesses, wound healing and other maladies common to man and animals. Sunshine is deemed a reliable source of quanta of photons, a likely physiologic prerequisite for multiple aspects of mammalian health and vitality. Sunlight is known to deliver photonic energy, and while not exactly a reliable cure-all, it may contribute as a healthful adjunct to the healing process.1-3 The oldest references to the benefits of sun therapy were reported on or before 1500 B.C. and as noted, references to multiple beneficial aspects of sun therapy continue to abound today. Although the molecular basis of photon-mediated therapies remain unclear or speculative, it is recognized that emerging findings of UV-derived light from sunlight or in vivo-derived sources now point to a nuclear disruptive element as a central factor in the ultimate wound healing process.

4,5 Depending on the intensity and wave-length of the UV exposure. it appears to impede further local replication of an invasive infectious agent, combined with an enhancement of immunologic responses in the UV- or sunlight-exposed host. Oxygen availability is deemed essential for optimal wound healing, and the associated immune responses are also likely linked at least in part to enhanced oxygen delivery to peripheral tissues.5

Dance-based Exercise Participation and Frailty

2025-03-28T17:01:03+00:00

Background: Aging is often deemed a declining state. But can dance participation in any form impact emergent or prevailing frailty among the older population?

Approach: A scoping review was conducted using the key words: dance, dance therapy, frailty, healthy aging, and older adults. Databases used were PubMed, PubMed Central and Google Scholar.

Results: Dance is a health fostering mode of activity that has been shown to impact cognitive and physical frailty, regardless of mode and population studied.

Conclusion: Dance participation is a health affirming activity that should be recommended for frailty prevention and mitigation albeit earlier rather than later, and for promoting healthy happy aging.

The methanolic extract of Shirazi thyme (Zataria Multiflora) and its combination with arsenic trioxide (ATO) changes the expression of onco-miRNAs and TS miRNAs in acute promyelocytic leukemia cell line (NB4)

2025-04-08T06:45:24+00:00

Acute promyelocytic leukemia (APL) is responsible for 10–15% of new AML cases. ATO is often used for recurrence after ATRA treatment but may cause complications. MicroRNAs (miRNAs) are crucial in various cancers. Zataria Multiflora (Shirazi thyme) is a medicinal plant that promotes apoptosis. This study investigates the effects of thyme's methanol extract and its combination with ATO on onco-MiRs and TS-MiRs in the NB4 cell line.

Cell viability and metabolic activity of NB4 cells were assessed via trypan blue dye exclusion test and MTT assay. Cell apoptosis rate was evaluated using flow cytometry, and changes in the expression of miRNAs 19a-3p, 23a-5p, 181b-5p, 3156-5p, and 4498 were analyzed through real-time PCR. Finally, docking was performed using MVD and HDOCK software. Combining ATO 0.25 µM with 20 µg/ml of Shirazi thyme extract significantly reduced cell viability, metabolic activity, and gene expression (except 181b-5p), while increasing apoptosis rates compared to individual treatments. These findings indicate that Zataria Multiflora can act as a synergistic adjuvant with ATO and, in some cases, produce superior effects compared to high doses of ATO alone. Docking results confirmed thymol and carvacrol as the potential compounds in the apoptotic effect of ZME.